“Alginate/chitosan core-shell beads with bioactive functionalities”

 

ABOUT PROJECT

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PROJECT PROMOTION 

FOUNDATION FOR POLISH SCIENCE

 

Agnieszka Kyzioł HOMEPAGE

                                

Since bacteria resistance depends on their aggregation in multicellular community of polysaccharides, proteins, metabolites, DNA etc. (biofilm), an innovative strategy is to develop therapies that can disrupt the complex structure of the biofilm. The multicellularity of the biofilm defeat assures infection overcoming by the host defence system and/or the restore of the antibiotics efficacy. Proposed potential therapy includes usage of the hydrolytic enzymes, that can dissolve the polymeric matrix of the biofilm and subsequent application of a well-known bacteria-sensitive antibiotic. In the presented project polymeric core-shell beads constructed of alginate core loaded with antibiotic and with chitosan shell with immobilized enzyme increasing biofilm susceptibility to antimicrobial agents are proposed as a new effective biomaterials to fight down resistant pathogenic microorganisms producing biofilm. In future, prepared and studied in the presented project alginate/chitosan beads can be applied in diabetic foot in form of aerosols, the most appropriate drug form in case of these serious chronic wounds.                  <more information>