| Research practical course in application of X-ray diffractometry and vibrational spectroscopy for structure studies of biologically active molecules | |
| Unit Code | ASC 23 semester III |
| Credits | 10 |
| Laboratory | Group of Crystal Chemistry of Drugs and Group of Oscillation Spectroscopy |
| Location | Faculty of Chemistry |
| Tutor name | Dr hab. Krzysztof Lewiński |
| Phone | 48-12-6632055 |
| birczyns@chemia.uj.edu.pl oleksyn@chemia.uj.edu.pl | |
COURSE DESCRIPTION: Practical course: Methods of crystallization; single crystal X-ray diffractometry, crystal structure solution and refinement, interpretation
of results; application of vibrational spectroscopy to study molecular structure and interactionsPractical course: Methods of crystallization; single crystal X-ray diffractometry,
crystal structure solution and refinement, interpretation of results; application of vibrational spectroscopy to study molecular structure and interactions.
AIMS:
The most important aims are: to acquaint students with methods of studying biologically important small molecules and drugs in different environments
and with experimental investigation of configuration, conformation and intermolecular interactions
INTENDED LEARNING OUTCOMES:
After completing this unit a student is expected to understand how the structure of small bioactive molecules may be determined
and how the results of structure investigations may be used to better understand the structure-activity relationships
TEACHING AND LEARNING ACTIVITIES:
Practice: 140 h
Seminar: 10h
Student centered learning: 100 h
Total student effort: 250 h
ASSESSMENT:
Written report (67 %), oral presentation (33 %)
BIBLIOGRAPHY:
Selected fragments of books, e.g. W. Clegg et all. “Crystal Strucre Analysis Principles and Practice”; G. L. Patrick “An Introduction to Medicinal Chemistry”; reviews and papers
in selected journals