COURSE DESCRIPTION: Neuropeptides and their physiological functions, Neuropeptide receptors, Maturation and metabolism of neuropeptides, Techniques used for studying neuropeptides and proteins (transgenic animals, antisense technologies, microinjections, behavioral tests), In-vitro quantitation of neuropeptides and proteins (radioimmunoassay, radioreceptorassay, antibodies, aptamers), Synthetic substrates and inhibitors of peptideses (peptide synthesis, peptidomimetics, combinatorial libraries) and their applications in pharmacology and medicine. Strategies for the optimal design of peptidase inhibitors, Strategies and techniques for isolation and analysis of neuropeptides and proteins
Practical course: Practicals include identification of endogenous compounds by means of a combination of ultrasensitive techniques, primary cell cultures (neurons and astrocytes), advanced separation techniques, proteomic strategies.

AIMS:

The major aims are to familiarize students with modern aspects of neuroscience, latest discoveries and also with basic knowledge, necessary to perform laboratory practicals

TEACHING AND LEARNING ACTIVITIES:

Practice: 140 h
Seminar: 10h
Student centered learning: 100 h
Total student effort: 250 h

ASSESSMENT:

Written report (67 %), oral presentation (33 %)

BIBLIOGRAPHY:

Lubert Stryer "Biochemistry"
George J. Siegel et al. Basic Neurochemistry-Molecular, Cellular, and medical Aspects

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