COURSE DESCRIPTION: The course combines theoretical and practical aspects of molecular mass spectrometry considered as a powerful analytical tool in various areas of chemistry. Essential instrumentation including working principles and performance of different types of ionization sources, analyzers, along with hyphenated techniques (GC-MS, LC-MS) are presented during the course. Furthermore, special techniques enabling the use of ion fragmentation phenomenon (including PSD, MS/MS) in structural study are illuminated. The presented material is complemented with numerous examples enabling to understand the ongoing processes as well as to acquaint a student with a wide range of potentials of mass spectrometry.

AIMS:

• To extend the students’ knowledge in mass spectrometry including both theoretical and practical aspects of the method
• To provide the basis for understanding of mass spectral processes and highlight the most recent developments in instrumentation
• To present application possibilities of mass spectrometry in various fields of chemistry and related disciplines
• To present adequate MS techniques for particular applications

INTENDED LEARNING OUTCOMES:
After completing this unit the student should be able to:

• Present an exhaustive and critical description of instrumentation used in molecular mass spectrometry including the most commonly used ionization techniques, types of analyzers as well as the techniques dedicated to sample introduction into a spectrometer
• Choose the most suitable mass spectrometry technique for a given application
• Interpret a mass spectral data providing a correctly drawn conclusion

TEACHING AND LEARNING ACTIVITIES:

Lectures, seminars and laboratory classes: 50 hours
Student centred learning: 75 hours
Total student effort: 125 hours

ASSESSMENT:

Examination on completion of teaching period: written or oral

RECOMMENDED READING:

• Introduction to Mass Spectrometry, J.T. Throck and O.D. Sparkman, 4th Edition, John Wiley & Sons, Chichester, 2007
• Mass Spectrometry: Principles and Applications, E. de Hoffmann and V. Stroobant, 3rd Edition, John Wiley & Sons, Chichester, 2007

RECOMMENDED WEBSITES:

http://masspec.scripps.edu/book_toc.php

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